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Paper Id: IJCIRAS1886
Title: REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN
Published in: International Journal Of Creative and Innovative Research In All Studies
Publisher: IJCIRAS
ISSN: 2581-5334
Volume / Issue: Volume 4 Issue 12
Pages: 12
Published On: 5/28/2022 6:06:27 AM      (MM/dd/yyyy)
Main Author Details
Name: Dr. Bharat .V. Jain
Institute: Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India
Co - Author Details
Author Name Author Institute
Mr. Tanveer .Y. Shaikh Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India
Mr. Siddhant .S. Tajane Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India
Dr. Sandip .R. Pawar Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: Fast Dissolving, Indomethacin, anti-inflammatory agent
Abstract: Indomethacin is class of non-steroidal anti- inflammatory drugs. It is act by inhibiting isoforms of cyclooxygenase 1 and 2. Indomethacin used in the treatment of moderate to severe rheumatoid arthritis including ankylosing spondylitis, osteoarthritis, tendinitis, bursitis and acute gouty arthritis etc. Indomethacin is practically insoluble in aqueous medium and highly permeable belong to BCS class II .Indomethacin shows very low and variable oral bioavailability due to poor dissolution in gastrointestinal fluid. This unwanted physical property of Indomethacin gives irritating side effects in gastrointestinal tract due to prolonged contact time with the mucosal layer of gastrointestinal tract. Solid dispersion methods are used to overcome this problem. Solid dispersion is commonly used technique to improve dissolution and bioavailability of poorly soluble drugs. The increase in dissolution rate for solid dispersion can be attributed to number of factors like particle porosity, particle size, wetting etc. Reduced particle size or reduced agglomeration, increased solubility or dissolution rate of poorly soluble drugs, Transferring drug from crystalline form to amorphous form, soluble complex formation in microenvironment, saturation of drug in microenvironment, Solubalisation of poorly soluble drug in presence of surfactant are some mechanisms of solid dispersion. From the past decades, there has been enhanced demand for more patients’ compliance dosage forms. Since the development cost of any new chemical drug is very high so for that reasons research and development department of many pharmaceutical companies focusing on the development of new drug delivery system for existing active ingredients. Novel drug delivery systems aims for designing and development of dosage forms, convenient to manufactured and administered ,with reduced side effects, offering rapid release and enhanced bioavailability so as to achieve better patient compliance. In recent years, innovative drug delivery systems, like ‘Fast Dissolving Tablets’ have been developed and attracted the interest of many researchers.
Citations
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IEEE
Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar, "REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN", International Journal Of Creative and Innovative Research In All Studies, vol. 4, no. 12, pp. 70-81, 2022.
MLA Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar "REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN." International Journal Of Creative and Innovative Research In All Studies, vol 4, no. 12, 2022, pp. 70-81.
APA Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar (2022). REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN. International Journal Of Creative and Innovative Research In All Studies, 4(12), 70-81.
REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN
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