ManuScript Details
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Paper Id:
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IJCIRAS2044
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Title:
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GINKGOLIDE-LOADED NANOEMULSION FOR INTRANASAL BRAIN DELIVERY: A REVIEW
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 9 Issue 1 |
| Pages: |
7
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| Published On: |
6/18/2026 9:59:35 PM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS2044.pdf |
Main Author Details
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Name:
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Mr. Gaurav Jijabrao Patil |
| Institute: |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India |
Co - Author Details
| Author Name |
Author Institute |
| Prof. Atul Sabe |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Ginkgolide, Nanoemulsion, Intranasal Delivery, Brain Targeting, Blood-Brain Barrier, Parkinson’s Disease, Neuroprotection. |
| Abstract: |
Neurological disorders such as Parkinson’s disease, Alzheimer’s disease, stroke, epilepsy, and dementia continue to represent a major global healthcare burden. The effective treatment of these disorders is significantly limited by the presence of the blood–brain barrier (BBB), which restricts the entry of most therapeutic agents into the central nervous system (CNS). Intranasal drug delivery has emerged as a promising non-invasive approach for direct brain targeting through the olfactory and trigeminal pathways, thereby bypassing the BBB. Nanoemulsions have attracted considerable attention as brain-targeting carriers due to their small droplet size, enhanced drug solubilization capacity, improved mucosal permeation, and ability to increase drug bioavailability. Ginkgolide, a diterpene lactone isolated from Ginkgo biloba, exhibits potent neuroprotective, antioxidant, anti-inflammatory, and anti-apoptotic activities. However, its therapeutic application is limited by poor aqueous solubility, low oral bioavailability, and restricted BBB penetration. The incorporation of Ginkgolide into intranasal nanoemulsion systems offers a promising strategy to improve brain targeting and therapeutic efficacy. This review discusses the pharmacological properties of Ginkgolide, the principles of nose-to-brain delivery, nanoemulsion technology, formulation considerations, recent advancements, challenges, and future prospects of Ginkgolide-loaded nanoemulsions for the management of neurological disorders. |
Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Mr. Gaurav Jijabrao Patil, Prof. Atul Sabe, "GINKGOLIDE-LOADED NANOEMULSION FOR INTRANASAL BRAIN DELIVERY: A REVIEW ", International Journal Of Creative and Innovative Research In All Studies,
vol. 9, no. 1, pp. 17-23, 2026.
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MLA
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Mr. Gaurav Jijabrao Patil, Prof. Atul Sabe "GINKGOLIDE-LOADED NANOEMULSION FOR INTRANASAL BRAIN DELIVERY: A REVIEW ." International Journal Of Creative and Innovative Research In All Studies,
vol 9, no. 1, 2026, pp. 17-23.
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APA
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Mr. Gaurav Jijabrao Patil, Prof. Atul Sabe (2026). GINKGOLIDE-LOADED NANOEMULSION FOR INTRANASAL BRAIN DELIVERY: A REVIEW . International Journal Of Creative and Innovative Research In All Studies,
9(1), 17-23.
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GINKGOLIDE-LOADED NANOEMULSION FOR INTRANASAL BRAIN DELIVERY: A REVIEW
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