ManuScript Details
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Paper Id:
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IJCIRAS1118
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Title:
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PREPARATION AND CHARACTERIZATION OF BIOACTIVE FUNCTIONALIZED SILK-BASED FILMS FOR WOUND HEALING
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 1 Issue 9 |
| Pages: |
14
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| Published On: |
2/21/2019 8:01:58 PM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1118.pdf |
Main Author Details
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Name:
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Sushma Adhikari, Sanjita Gautam, Shubham Subedi, Nita Shrestha, Soni Nagarkoti, Prakash Gautam |
| Institute: |
College of Biomedical Engineering and Applied Sciences |
Co - Author Details
| Author Name |
Author Institute |
| Mishal Pokharel |
College of Biomedical Engineering and Applied Sciences |
Abstract
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Research Area:
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Polymer Engineering |
| KeyWord: |
Hydrophilicity, Functionalize,Pathological,Proliferation
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| Abstract: |
In this study, an effort has been made to develop a ready-to-use bioactive wound dressing material using natural silk fibroin biomaterial functionalized with drugs and PRP.The flexible silk films were prepared by incorporating 3% dextrose (w/w) in the silk films which acted as a plasticizer. The dextrose modified silk films showed higher water holding capacity than the normal silk films. After evaluating the results of the comparative study done in between the silk films and the dextrose modified silk films, it was found that the flexibility as well as the hydrophilicity of silk fibroin films increased upon the addition of dextrose. Additionally, two more types of dextrose modified films were prepared, the PRP coated dextrose modified films and the drug coated dextrose modified films. The films were microscopically examined for detecting cytotoxicity and the results showed that the films were not toxic. An in-vivo wound healing test on mice models indicated that the PRP coated and the drug coated films resulted in a good wound recovery effect, similar to a commercial wound dressing material. The increased hydrophilicity of these films along with the combined results of drugs and PRP have balanced the moist environment at the wound site, which improved the wound healing compared with the other types of films. This systematic approach to wound healing biomaterial wound dressings may demonstrate a useful strategy to select formulations for further study towards new treatment options for chronic wounds in the future.
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Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Sushma Adhikari, Sanjita Gautam, Shubham Subedi, Nita Shrestha, Soni Nagarkoti, Prakash Gautam, Mishal Pokharel, "PREPARATION AND CHARACTERIZATION OF BIOACTIVE FUNCTIONALIZED SILK-BASED FILMS FOR WOUND HEALING", International Journal Of Creative and Innovative Research In All Studies,
vol. 1, no. 9, pp. 78-91, 2019.
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MLA
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Sushma Adhikari, Sanjita Gautam, Shubham Subedi, Nita Shrestha, Soni Nagarkoti, Prakash Gautam, Mishal Pokharel "PREPARATION AND CHARACTERIZATION OF BIOACTIVE FUNCTIONALIZED SILK-BASED FILMS FOR WOUND HEALING." International Journal Of Creative and Innovative Research In All Studies,
vol 1, no. 9, 2019, pp. 78-91.
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APA
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Sushma Adhikari, Sanjita Gautam, Shubham Subedi, Nita Shrestha, Soni Nagarkoti, Prakash Gautam, Mishal Pokharel (2019). PREPARATION AND CHARACTERIZATION OF BIOACTIVE FUNCTIONALIZED SILK-BASED FILMS FOR WOUND HEALING. International Journal Of Creative and Innovative Research In All Studies,
1(9), 78-91.
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PREPARATION AND CHARACTERIZATION OF BIOACTIVE FUNCTIONALIZED SILK-BASED FILMS FOR WOUND HEALING
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