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Paper Id: IJCIRAS1872
Title: A STUDY TO EVALUATE THE SAFETY AND CYTOTOXICITY OF 'ORAL POLIO VACCINE"
Published in: International Journal Of Creative and Innovative Research In All Studies
Publisher: IJCIRAS
ISSN: 2581-5334
Volume / Issue: Volume 4 Issue 11
Pages: 8
Published On: 5/24/2022 9:56:20 PM      (MM/dd/yyyy)
Main Author Details
Name: Mr. Mohd. Zeeshan
Institute: Amity University Noida Private university in Noida, Uttar Pradesh
Co - Author Details
Author Name Author Institute
Mr. Suraj Chaudhari Amity University Noida Private university in Noida, Uttar Pradesh
Mr. Aakash Lalwani Indian Institute of Technology Kanpur
Mr. Aditya Pawar R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur , Dhule , MH
Abstract
Research Area: Internal medicine
KeyWord: Polio, Bivalent (OPV), Quality imputed, Sterility, GPT.
Abstract: Live attenuated oral polio vaccine (OPV) is used to eradicate the polio disease. Live, oral poliomyelitis vaccine is a clear apparent or light pink colored solution, attenuated poliomyelitis viruses (Sabin strains) which was propagated in primary monkey kidney cell culture (P.M.K.C.C). The main aim of the study was to generate bivalent oral polio vaccine for oral administration purpose. We have investigated various quality parameters like sterility, media preparation, microbial monitoring, GPT (growth promoting test), water drop, vaccine drop test, pH and kanamycin antibiotic activity. There are three serotypes of poliovirus have been identified as (PV1), (PV2), (PV3) each serotype with a slightly different in capsid protein. [3] The disease mostly transmits via fecal-oral route (INTESTINAL SOURCE) and the oral-oral route (OROPHARYNGAL SOURCE) Poliovirus come into oropharynx and proliferates in tonsils, lymph node of the neck after that in Peyer patches and small intestine. A medical rotation came after produced polio vaccine in 1950 by Salk and Sabin, presently two types of vaccine fit for the medical care of children purpose by several administration routes such as Oral Polio Vaccine (OPV) for oral route and Inactivated Polio Vaccine (IPV) for injectable administration. Our study potentially suggest that this bivalent vaccine is able to inactivate all virus strains spread among the country and passed all parameters and the study may help to maintain cold chain during transportation and storage of vaccine.
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IEEE
Mr. Mohd. Zeeshan , Mr. Suraj Chaudhari, Mr. Aakash Lalwani , Mr. Aditya Pawar , "A STUDY TO EVALUATE THE SAFETY AND CYTOTOXICITY OF 'ORAL POLIO VACCINE"", International Journal Of Creative and Innovative Research In All Studies, vol. 4, no. 11, pp. 21-28, 2022.
MLA Mr. Mohd. Zeeshan , Mr. Suraj Chaudhari, Mr. Aakash Lalwani , Mr. Aditya Pawar "A STUDY TO EVALUATE THE SAFETY AND CYTOTOXICITY OF 'ORAL POLIO VACCINE"." International Journal Of Creative and Innovative Research In All Studies, vol 4, no. 11, 2022, pp. 21-28.
APA Mr. Mohd. Zeeshan , Mr. Suraj Chaudhari, Mr. Aakash Lalwani , Mr. Aditya Pawar (2022). A STUDY TO EVALUATE THE SAFETY AND CYTOTOXICITY OF 'ORAL POLIO VACCINE". International Journal Of Creative and Innovative Research In All Studies, 4(11), 21-28.
A STUDY TO EVALUATE THE SAFETY AND CYTOTOXICITY OF 'ORAL POLIO VACCINE"
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