ManuScript Details
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Paper Id:
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IJCIRAS2045
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Title:
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REVIEW OF TERPINEN-4-OL LOADED NANOGELS: A PROMISING APPROACH FOR TOPICAL MANAGEMENT OF DERMATOPHYTIC AND CANDIDAL INFECTIONS
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 9 Issue 1 |
| Pages: |
6
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| Published On: |
6/24/2026 9:09:08 PM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS2045.pdf |
Main Author Details
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Name:
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Mr. Dinesh Vilas Patil |
| Institute: |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India |
Co - Author Details
| Author Name |
Author Institute |
| Dr. Bharat V. Jain |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Terpinen-4-ol;Antifunga lNanogel; Nanotechnology; Dermatophytosis; Candida albicans; Skin Penetration; Sustained Drug Release; Topical Drug Delivery; Tea Tree Oil; Novel Drug Delivery System; Antifungal Therapy; Nanocarriers. |
| Abstract: |
Superficial fungal infections caused by dermatophytes and Candida species represent a major global health concern, affecting millions of individuals and significantly reducing quality of life. Conventional topical antifungal therapies often suffer from limitations such as inadequate skin penetration, poor drug retention at the site of infection, frequent application requirements, and reduced therapeutic efficacy. Terpinen-4-ol, the principal bioactive constituent of Melaleuca alternifolia (Tea Tree Oil), possesses potent antifungal, antimicrobial, and anti-inflammatory properties. However, its therapeutic application is restricted due to poor aqueous solubility, high volatility, chemical instability, and rapid evaporation from the skin surface.
The present study aims to formulate, optimize, and evaluate a Terpinen-4-ol-loaded antifungal nanogel for enhanced skin penetration, improved antifungal efficacy, and sustained local drug release against dermatophytic and candidal infections. Nanogel technology offers a promising platform by combining the advantages of nanosized drug carriers with the favorable characteristics of hydrogels, thereby facilitating improved dermal delivery, prolonged drug retention, controlled release, and enhanced patient compliance. The proposed Terpinen-4-ol-loaded nanogel is anticipated to overcome the limitations associated with conventional topical formulations by enhancing skin penetration, protecting the active compound from degradation, providing sustained drug release, and improving antifungal effectiveness. Thus, the developed nanogel system may serve as a promising and innovative approach for the effective management of superficial fungal infections and contribute to the advancement of nanotechnology-based topical antifungal therapy.
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Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Mr. Dinesh Vilas Patil, Dr. Bharat V. Jain, "REVIEW OF TERPINEN-4-OL LOADED NANOGELS: A PROMISING APPROACH FOR TOPICAL MANAGEMENT OF DERMATOPHYTIC AND CANDIDAL INFECTIONS ", International Journal Of Creative and Innovative Research In All Studies,
vol. 9, no. 1, pp. 24-29, 2026.
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MLA
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Mr. Dinesh Vilas Patil, Dr. Bharat V. Jain "REVIEW OF TERPINEN-4-OL LOADED NANOGELS: A PROMISING APPROACH FOR TOPICAL MANAGEMENT OF DERMATOPHYTIC AND CANDIDAL INFECTIONS ." International Journal Of Creative and Innovative Research In All Studies,
vol 9, no. 1, 2026, pp. 24-29.
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APA
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Mr. Dinesh Vilas Patil, Dr. Bharat V. Jain (2026). REVIEW OF TERPINEN-4-OL LOADED NANOGELS: A PROMISING APPROACH FOR TOPICAL MANAGEMENT OF DERMATOPHYTIC AND CANDIDAL INFECTIONS . International Journal Of Creative and Innovative Research In All Studies,
9(1), 24-29.
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REVIEW OF TERPINEN-4-OL LOADED NANOGELS: A PROMISING APPROACH FOR TOPICAL MANAGEMENT OF DERMATOPHYTIC AND CANDIDAL INFECTIONS
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