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Paper Id: IJCIRAS1273
Title: LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE
Published in: International Journal Of Creative and Innovative Research In All Studies
Publisher: IJCIRAS
ISSN: 2581-5334
Volume / Issue: Volume 2 Issue 1
Pages: 13
Published On: 6/29/2019 4:47:06 AM      (MM/dd/yyyy)
Main Author Details
Name: Md. Saifuzzaman Sazib
Institute: Department of Pharmacy, Jagannath University, Dhaka, Bangladesh.
Co - Author Details
Author Name Author Institute
Md. Islam Molla Department of Pharmacy, Jagannath University, Dhaka, Bangladesh.
Parimal Talukder Research and Development Division, Beacon Pharmaceuticals Ltd, Bangladesh
Mrityunjoy Biswas Dept. of Microbilogy And Immunology, Aichi Medical University
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: Lyophilized injection, Bioavailability, Metastatic Melanoma, Dacarbazine
Abstract: To improve the bioavailability, stability, solubility and patient compliance lyophilized injection dosage form is extensively used in pharmaceutical industry. For better patient satisfaction particularly in bed ridden patients and for achieving maximum bioavailability the lyophilized injection has been considered as substitute to oral solid dosage forms. Lyophilization or freeze drying involves the elimination of water or other solvent from a frozen product by a process called sublimation followed by desorption. Freeze drying is a multistage process in which, quite obviously, each stage is critical. The key actors of this scenario are all recognized and should be under strict to complete a successful operation. Lyophilized products for parenteral use are known as Powders for injection or infusion. Dacarbazine is an alkylating agent administered as a first-line treatment for metastatic melanoma. As the stability of Dacarbazine in aqueous solution form was unstable it was formulated as Lyophilized product. The objective of the present study was to develop a stable lyophilized formulation of drug Dacarbazine for injection (200mg/vial).
Citations
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IEEE
Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas, "LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE", International Journal Of Creative and Innovative Research In All Studies, vol. 2, no. 1, pp. 35-47, 2019.
MLA Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas "LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE." International Journal Of Creative and Innovative Research In All Studies, vol 2, no. 1, 2019, pp. 35-47.
APA Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas (2019). LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE. International Journal Of Creative and Innovative Research In All Studies, 2(1), 35-47.
LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE
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